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Barrett's esophagus is a condition in which there is an abnormal (metaplastic) change in the mucosal cells lining the lower portion of the esophagus, from stratified squamous epithelium to simple columnar epithelium with interspersed goblet cells that are normally present only in the small intestine and large intestine.
The excessive mucus production seen in allergic asthma patients is due to goblet cell metaplasia, the differentiation of airway epithelial cells into mucin producing goblet cells. [17] These cells produce the thick mucins MUC5AC and MUC5B , which clog the airway, leading to the airflow obstruction characteristic of asthma .
Intestinal metaplasia; Histopathology of Barrett's esophagus, showing intestinalized epithelium with Goblet cells, as opposed to normal stratified squamous epithelium of the esophagus, and pseudostratified columnar epithelium of the fundus of the stomach. H&E stain.
When cells are faced with physiological or pathological stresses, they respond by adapting in any of several ways, one of which is metaplasia. It is a benign (i.e. non-cancerous) change that occurs as a response to change of milieu (physiological metaplasia) or chronic physical or chemical irritation.
Interleukin-13 has a critical role in goblet cell metaplasia. [12] Goblet cells are filled with mucin (MUC). [12] MUC5AC Mucin 5AC is a gel-like mucin product of goblet cells. [12] Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium.
GLP-1s affect cells in a tiny V-shaped structure in your brain stem. This zone is a chemoreceptor—a spot that makes you feel like hurling when it meets something it doesn’t like, says Kevin ...
The two main types of hyperplastic polyps are microvesicular mucin-rich type and goblet cell-rich type. [1] A mucin-poor type with eosinophilic cytoplasm, which is rare, was previously described. [4] However, the mucin poor type is no longer considered a distinct subtype. [1]
Reviewed by Dietitian Annie Nguyen, M.A., RD. Your heart is arguably the hardest-working muscle in your body. Every day it pumps nearly 2,000 gallons of blood through your arteries to supply the ...