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Metronidazole, sold under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. [10] It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. [10] It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. [10]
Bacterial vaginosis: The most commonly used antibiotics are metronidazole, available in both pill and gel form, and clindamycin available in both pill and cream form. [11] Yeast infections: Local azole, in the form of ovula and cream. All agents appear to be equally effective. [33]
BV is a risk factor for viral shedding and herpes simplex virus type 2 infection. BV may increase the risk of infection with or reactivation of human papillomavirus (HPV). [22] [24] In addition, bacterial vaginosis as either pre-existing, or acquired, may increase the risk of pregnancy complications, most notably premature birth or miscarriage.
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Structurally it actually methyl-metronidazole. Effectiveness in the treatment of dientamoebiasis has been reported. [1] It has also been tested against Atopobium vaginae. [2] In the United States, secnidazole is FDA approved for the treatment of bacterial vaginosis and trichomoniasis in adult women. [3]
TOL-463 is an anti-infective medication which is under development for the treatment of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) (vaginal yeast infection). [ 3 ] [ 1 ] [ 4 ] [ 2 ] It is a boric acid -based vaginal anti-infective enhanced with ethylenediaminetetraacetic acid (EDTA) which was designed to have improved activity ...