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Methotrexate. 60% at lower doses, less at higher doses. [7] Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. [4] It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. [4] Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational ...
Physiologically based pharmacokinetic modelling. Graphic representation of a physiologically based whole body model. Here, it is dissected into seven tissue/organ compartments: brain, lungs and heart, pancreas, liver, gut, kidney and adipose/muscle tissue. Blood flows, Q, and concentration, [X], of a substance of interest are depicted.
Clearance (pharmacology) In pharmacology, clearance ( ) is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [1] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
Elimination (pharmacology) In pharmacology, the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite. The kidney is the main excretory organ although others ...
Folinic acid. Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. [2][3] It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. [3][4] It ...
Table of volume of distribution for drugs. This is a table of volume of distribution (V d) for various medication. For comparison, those with a V d L/kg body weight of less than 0.2 are mainly distributed in blood plasma, 0.2-0.7 mostly in the extracellular fluid and those with more than 0.7 are distributed throughout total body water. Medication.
Drugs secreted in the kidney. This is a table of drugs that are secreted in the kidney. Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic. Medication.
Pharmacokinetics is based on mathematical modeling that places great emphasis on the relationship between drug plasma concentration and the time elapsed since the drug's administration. Pharmacokinetics is the study of how an organism affects the drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism.