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A significant risk of megaloblastic anaemia exists with doses of pyrimethamine in excess of 25 mg/wk. Antivirals, more specifically, lamivudine (increased plasma concentrations of lamivudine), zalcitabine (increased plasma concentrations of zalcitabine) and zidovudine (increased risk of haematological reactions)
Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
However, the half-life of the drug noticeably increases in people with creatinine clearance rates equal to or less than 30 mL/minute. A half-life of 22–50 hours has been reported for people with creatinine clearances of less than 10 mL/minute. [11] Metabolism. Sulfamethoxazole is metabolized in the human liver to at least 5 metabolites.
Brucellosis [4] is a zoonosis caused by ingestion of unpasteurized milk from infected animals, or close contact with their secretions. [5] It is also known as undulant fever, Malta fever, and Mediterranean fever. [6] The bacteria causing this disease, Brucella, are small, Gram-negative, nonmotile, nonspore-forming, rod-shaped (coccobacilli ...
They are small (0.5 to 0.7 by 0.6 to 1.5 μm), non-encapsulated, non-motile, [4] facultatively intracellular coccobacilli. Brucella spp. are the cause of brucellosis , which is a zoonosis transmitted by ingesting contaminated food (such as unpasteurized milk products), direct contact with an infected animal, or inhalation of aerosols.
The following is a list of antibiotics.The highest division between antibiotics is bactericidal and bacteriostatic.Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing.
Brucella melitensis is a Gram-negative coccobacillus bacterium from the Brucellaceae family. The bacterium causes ovine brucellosis , along with Brucella ovis . Humans can become infected if they have contact with an infected animal or its byproducts.
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