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Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. [4][5] These areas are red, pink, or purple, dry, itchy, and scaly. [8][3] Psoriasis varies in severity from small localized patches to complete body coverage. [3] Injury to the skin can trigger psoriatic skin changes at that spot, which is ...
Secukinumab inhibits a member of the cytokine family, interleukin 17A, which is produced mainly by inflammatory T helper 17 cells. [11] IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and promotes inflammation when it binds to the interleukin-17 receptor which is expressed in various types of cells, including keratinocytes in ...
D10438. Chemical and physical data. Formula. C6402H9864N1676O1994S42. Molar mass. 143 561.59 g·mol −1. Guselkumab, sold under the brand name Tremfya, is a monoclonal antibody against interleukin-23 used for the treatment of plaque psoriasis, psoriatic arthritis, and ulcerative colitis. [7][8][9]
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Risankizumab, sold under the brand name Skyrizi, is a humanized monoclonal antibody used for the treatment of plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. [6][7] It is designed to target interleukin 23A (IL-23A). [6][7][9] It is given by subcutaneous injection. [6][7] The most common side effects include upper ...
Psoriatic arthritis (PsA) is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis. [1][2] The classic feature of psoriatic arthritis is swelling of entire fingers and toes with a sausage-like appearance ("sausage digit"). [3]
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