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Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
Besides the simple oxide CaO, calcium peroxide, CaO 2, can be made by direct oxidation of calcium metal under a high pressure of oxygen, and there is some evidence for a yellow superoxide Ca(O 2) 2. [16] Calcium hydroxide, Ca(OH) 2, is a strong base, though not as strong as the hydroxides of strontium, barium or the alkali metals. [17]
Calcium channel blocker toxicity is the taking of too much of the medications known as calcium channel blockers (CCBs), either by accident or on purpose. [3] This often causes a slow heart rate and low blood pressure. [1] This can progress to the heart stopping altogether. [2]
Toxic in some forms; pure phosphorus is poisonous to humans. [11] platinum: 78: 2c: Has no known biological role, but it is a component of the drug cisplatin, which is highly effective in treating some forms of cancer. [11] Toxic in some forms. Contact can promote an allergic reaction in humans. [11] plutonium: 94: 1bc
Another damaging result of excess calcium in the cytosol is the opening of the mitochondrial permeability transition pore, a pore in the membranes of mitochondria that opens when the organelles absorb too much calcium. Opening of the pore may cause mitochondria to swell and release reactive oxygen species and other proteins that can lead to ...
Toxic metals can bioaccumulate in the body and in the food chain. [5] Therefore, a common characteristic of toxic metals is the chronic nature of their toxicity. This is particularly notable with radioactive heavy metals such as radium , which imitates calcium to the point of being incorporated into human bone, although similar health ...