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Pseudohyphae are distinguished from true hyphae by their method of growth, relative frailty and lack of cytoplasmic connection between the cells. Yeasts form pseudohyphae. [ 10 ] They are the result of a sort of incomplete budding where the cells elongate but remain attached after division.
A blastoconidium (plural blastoconidia) is an asexual holoblastic conidia formed through the blowing out or budding process of a yeast cell, which is a type of asexual reproduction that results in a bud arising from a parent cell. [1] [2] The production of a blastoconidium can occur along a true hyphae, pseudohyphae, or a singular yeast cell. [3]
Some yeast species have the ability to develop multicellular characteristics by forming strings of connected budding cells known as pseudohyphae or false hyphae, or quickly evolve into a multicellular cluster with specialised cell organelles function.
As blastoconidia increase in number they may elongate in shape producing structures called the pseudohyphae. [3] [4] Under specific conditions of reduced oxygen level in host tissues, submerged colonies in agar medium, or in the presence of 5-10% CO 2, true, septate hyphae may form. [10] [3]
[49] [50] [51] The transition from yeast to hyphal cells is termed to be one of the key factors in the virulence of C. albicans; however, it is not deemed necessary. [52] When C. albicans cells are grown in a medium that mimics the physiological environment of a human host, they grow as filamentous cells (both true hyphae and pseudohyphae).
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Brushing or biopsy of the plaques shows yeast and pseudohyphae by histology that are characteristic of Candida species. A severe case of candidiasis H&E stain of esophagus showing Candida hyphae within the lamina propria
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