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Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
The symptoms and signs associated with convergence insufficiency are related to prolonged, visually demanding, near-centered tasks. They may include, but are not limited to, diplopia (double vision), asthenopia (eye strain), transient blurred vision, difficulty sustaining near-visual function, abnormal fatigue, headache, and abnormal postural adaptation, among others.
Up to 5% of patients with hereditary retinoblastoma are at risk of developing trilateral retinoblastoma. [10] This tumor combination is more aggressive than an isolated pineoblastoma. [ 4 ] Prognosis of patients with trilateral retinoblastoma is dismal, only a few patients have survived more than 5 years after diagnosis; all survivors were ...
Symptoms: Blurred or no vision in the center of the visual field [1] Complications: Visual hallucinations [1] Usual onset: Older people [1] Types: Early, intermediate, late [1] Causes: Damage to the macula of the retina [1] Risk factors: Genetics, smoking [1] Diagnostic method: Eye examination [1] Prevention: Exercising, eating well, not ...
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
For example, adolescents and young adults with acute lymphoblastic leukemia (ALL) may have better outcomes if they are treated with pediatric treatment protocols rather than adult treatment protocols. The 5-year survival rates for 15- to 19-year-olds with ALL has risen to 74% as of 2007–2013, from survival rates of around 50% in the early 1990s.
The most common symptoms of CNS tumors are headache, vomiting, and nausea. Symptoms vary depending on the tumor and may include unsteady gait, slowed speech, memory loss, loss of hearing and vision, problems with memory, narrowing of visual field, and back pain. Symptoms may also vary greatly between individuals with the same tumor type.
In general, treatment can include surgical resection, [39] chemotherapy, [40] radiation therapy, [41] or immunotherapy. [42] Recent medical advances have improved our understanding of the genetic basis of childhood cancers. Treatment options are expanding, and precision medicine for childhood cancers is a rapidly growing area of research. [43]
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