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Polysorbate 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone . [ 9 ]
Polysorbate 60 (polyoxyethylene (20) sorbitan monostearate) Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate) The number following the 'polysorbate' part is related to the type of major fatty acid associated with the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80.
Coating these polymeric nanoparticle devices with different surfactants can also aid BBB crossing and uptake in the brain. Surfactants such as polysorbate 80, 20, 40, 60, and poloxamer 188, demonstrated positive drug delivery through the blood–brain barrier, whereas other surfactants did not yield the same results. [2]
Examples synthesized on an industrial scale include octyl phenol ethoxylate, polysorbate 80 and poloxamers. Ethoxylation is commonly practiced, albeit on a much smaller scale, in the biotechnology and pharmaceutical industries to increase water solubility and, in the case of pharmaceuticals, circulatory half-life of non-polar organic compounds.
The chemical structure shown for Polysorbate 80 appears to be incorrect. Polysorbate 80 is made by polymerization of 20 equivalents of ethylene oxide with sorbitan monooleate [1]. The method of synthesis is summarized in Chapter 2 of Food Emulsifiers and Their Applications: Hasenhuettl, Gerard L., Hartel, Richard W. (Eds.) [2]. Aside from the ...
Sorbitan is produced by the dehydration of sorbitol and is an intermediate in the conversion of sorbitol to isosorbide.The dehydration reaction usually produces sorbitan as a mixture of five- and six-membered cyclic ethers (1,4-anhydrosorbitol, 1,5-anhydrosorbitol and 1,4,3,6-dianhydrosorbitol) [3] with the five-membered 1,4-anhydrosorbitol form being the dominant product.
Polysorbate 20 – emulsifier; Polysorbate 40 – emulsifier; Polysorbate 60 – emulsifier; Polysorbate 65 – emulsifier; Polysorbate 80 – emulsifier; Polyvinylpolypyrrolidone – color stabiliser; Pomegranate seeds (though some consider these a fruit, not a spice) – Ponceau 4R – color (FDA: Ext D&C Red #8) Ponceau 6R – color; Ponceau ...
Sorbitan monooleate (commercially: Span® 80; Croda International PLC) is a nonionic surfactant and emulsifier widely used in various industries, including food, pharmaceuticals, and cosmetics. It is a sorbitan ester produced by the esterification of sorbitan with oleic acid, resulting in a light yellow, viscous liquid that is insoluble in ...