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Given the success of the IPI for intermediate grade lymphomas, an effort was undertaken to develop a similar prognostic index for the most common low-grade lymphoma, follicular lymphoma. The prognostic factors that emerged from this were: age, stage, number of lymph node areas involved, serum hemoglobin level, and serum LDH.
The two major types of Hodgkin lymphoma are classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. [5] About half of cases of Hodgkin lymphoma are due to Epstein–Barr virus (EBV) and these are generally the classic form. [3] [11] Other risk factors include a family history of the condition and having HIV/AIDS.
Because of the prolonged survival, which was typically about 10 years in past decades, but which can extend to a normal life expectancy, [2] the prevalence (number of people living with the disease) is much higher than the incidence (new diagnoses). CLL is the most common type of leukemia in the UK, accounting for 38% of all leukemia cases.
Risk factors for Hodgkin lymphoma include infection with Epstein–Barr virus and a history of the disease in the family. [1] Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases , HIV/AIDS , infection with human T-lymphotropic virus , immunosuppressant medications , and some pesticides .
Boys with X-linked immunodeficiency syndrome are at a higher risk of mortality associated with Epstein–Barr virus infections, and are predisposed to develop a lymphoproliferative disorder or lymphoma. [citation needed] Children with common variable immunodeficiency (CVID) are also at a higher risk of developing a lymphoproliferative disorder.
Aggressive lymphoma, also known as high-grade lymphoma, is a group of fast growing non-Hodgkin lymphoma. [1]There are several subtypes of aggressive lymphoma. These include AIDS-associated lymphoma, angioimmunoblastic lymphoma, Burkitt lymphoma, central nervous system (CNS) lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and peripheral T-cell lymphoma. [1]
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