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It is commonly accepted that the MFB is a part of the reward system, involved in the integration of reward and pleasure. [4] Electrical stimulation of the medial forebrain bundle is believed to cause sensations of pleasure. This hypothesis is based upon intracranial self-stimulation (ICSS) studies. Animals will work for MFB ICSS, and humans ...
The lateral hypothalamus is a portion of the hypothalamus, and brain stimulation to this area at the level of the medial forebrain bundle produces the highest response rates and subsequently the highest reward potency in rodents. Lesions in this region or along its boundary cause a loss of positive drive-reward behaviors as well as all other ...
It is one of the component pathways of the medial forebrain bundle, which is a set of neural pathways that mediate brain stimulation reward. [10] The VTA is located in the midbrain and consists of dopaminergic, GABAergic, and glutamatergic neurons. [11]
The medial forebrain bundle, which is a set of many neural pathways that mediate brain stimulation reward (i.e., reward derived from direct electrochemical stimulation of the lateral hypothalamus), is also a component of the reward system. [24]
The main dopaminergic pathways of the human brain. Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control. [1]
Other axons arising from these cells descend through the medial forebrain bundle to terminate in a region dorsal to the interpeduncular nucleus. The lateral septum is a relay center for connections from the CA3 of the hippocampus to the ventral tegmental area. [9] [10] These connections help link reward signals with the context in which they occur.
The dopamine reward circuitry in the human brain involves two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. First, the posteromedial VTA and central linear raphe cells selectively project to the ventromedial striatum, which includes the medial olfactory tubercle and the medial NAC shell.
Medial forebrain bundle; Medial longitudinal fasciculus; Myoclonic triangle; Solitary tract; Major dopaminergic pathways from dopaminergic cell groups. Mesocortical pathway; Mesolimbic pathway; Nigrostriatal pathway; Tuberoinfundibular pathway; Serotonergic pathways. Raphe Nuclei; Norepinephrine Pathways Locus coeruleus and other noradrenergic ...