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The scarring of the small blood vessels, called capillary sclerosis, is the initial lesion of analgesic nephropathy. [7] Found in the renal pelvis, ureter, and capillaries supplying the nephrons, capillary sclerosis is thought to lead to renal papillary necrosis and, in turn, chronic interstitial nephritis.
Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II's vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma volume, and thereby RPF)—the so-called "triple whammy" effect. [82] In rarer instances NSAIDs may also cause more severe kidney ...
According to Cleveland Clinic, you should also avoid taking NSAIDs if you are pregnant, or have a history of stroke or heart attack, heart failure, stomach ulcers, Crohn’s disease or ulcerative ...
Chronic kidney disease (CKD) is a type of long-term kidney disease, ... [16] [10] [17] NSAIDs should be avoided. [10] Other recommended measures include staying ...
Chronic kidney disease. Renal artery stenosis (when the artery leading to your kidney is narrowed) ... (NSAIDs), like ibuprofen and aspirin. Race. You have a higher risk of high blood pressure if ...
Chronic kidney disease. Kidney stones. Osteoarthritis. ... Nonsteroidal anti-inflammatory drugs (NSAIDs), which are available OTC and include ibuprofen (Advil, Motrin) and naproxen (Aleve)