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A randomized controlled trial (or randomized control trial; [2] RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical techniques, medical devices , diagnostic procedures , diets or other medical treatments.
"A/B testing" is a shorthand for a simple randomized controlled experiment, in which a number of samples (e.g. A and B) of a single vector-variable are compared. [1] A/B tests are widely considered the simplest form of controlled experiment, especially when they only involve two variants.
Randomized controlled trial, a research method used in medical and social sciences; Radiochemotherapy, the combination of chemotherapy and radiotherapy to treat cancer; Root canal treatment, dental treatment to treat nerve damage of the tooth
In the statistical theory of design of experiments, randomization involves randomly allocating the experimental units across the treatment groups.For example, if an experiment compares a new drug against a standard drug, then the patients should be allocated to either the new drug or to the standard drug control using randomization.
In medicine an intention-to-treat (ITT) analysis of the results of a randomized controlled trial is based on the initial treatment assignment and not on the treatment eventually received. ITT analysis is intended to avoid various misleading artifacts that can arise in intervention research such as non-random attrition of participants from the ...
A cluster-randomised controlled trial is a type of randomised controlled trial in which groups of subjects (as opposed to individual subjects) are randomised. [1] Cluster randomised controlled trials are also known as cluster-randomised trials, [2] group-randomised trials, [3] [4] and place-randomized trials. [5]
The Mendelian randomization method depends on two principles derived from the original work by Gregor Mendel on genetic inheritance. Its foundation come from Mendel’s laws namely 1) the law of segregation in which there is complete segregation of the two allelomorphs in equal number of germ-cells of a heterozygote and 2) separate pairs of allelomorphs segregate independently of one another ...
Randomized, controlled, crossover experiments are especially important in health care. In a randomized clinical trial, the subjects are randomly assigned treatments. When such a trial is a repeated measures design, the subjects are randomly assigned to a sequence of treatments.