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For maintenance, take 1 serving (5,000 mg) immediately after training." ... The idea behind this is that your muscles will rapidly increase its creatine stores, and then later doses will maintain ...
To avoid potential side effects, experts recommend taking 5g of creatine daily long-term. This maintenance dose has been shown in practice to provide benefits without the side effects of a large dose.
This maintenance dose was originally reported to be around 2–3 g/day (or 0.03 g/kg/day), [20] however, some studies have suggested 3–5 g/day maintenance dose to maintain saturated muscle creatine.
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In pharmacokinetics, a maintenance dose is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with dose regimen , which is a type of drug therapy in which the dose [mg] of a drug is given at a regular dosing interval on a repetitive basis.
Creatinine itself is produced [5] via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine triphosphate (ATP, the body's immediate energy supply). Creatine is synthesized primarily in the liver by methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids ...