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In general, cytotoxic edema is linked to cell death in the brain through excessive cellular swelling. [1] During cerebral ischemia for example, the blood–brain barrier remains intact but decreased blood flow and glucose supply leads to a disruption in cellular metabolism and creation of energy sources, such as adenosine triphosphate (ATP). [1]
Brain death is the permanent, irreversible, and complete loss of brain function, ... temporary swelling of the brain, particularly within the first 72 hours, ...
The actual mechanism behind the catastrophic brain swelling is controversial. [23] [24] A second injury during this time is thought to unleash a series of metabolic events within the brain. [25] [better source needed] Changes indicative of SIS may begin occurring in the injured brain within 15 seconds of the second concussion. [26]
A spokesperson told the newspaper that a Friday autopsy found the provisional cause of death to be hypoxic brain damage and cerebral edema, meaning brain swelling. "The brain was massively damaged ...
“A Georgia resident has died from Naegleria fowleri infection, a rare infection which destroys brain tissue, causing brain swelling and usually death,” the health department said in a news ...
If the swelling is untreated, it causes death by brain herniation. [4] The brain swelling is likely a result of vasogenic edema, the penetration of the blood–brain barrier by fluids. [16] This process has been observed in MRI studies. Hypoxia increases extracellular fluid, which passes through the vasogenic endothelium in the brain.
Lee's death was officially ruled the result of cerebral edema — swelling of the brain. While a normal human brain is about 3 pounds, Lee's was reportedly closer to 3½ pounds.
Ischemic hypoxia can also be created by pressure on the brain. Cerebral edema, brain hemorrhages and hydrocephalus exert pressure on brain tissue and impede their absorption of oxygen. Histotoxic hypoxia – Oxygen is present in brain tissue but cannot be metabolized by the brain tissue. Cyanide poisoning is a well-known example.