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Ketoconazole has additionally been used, in lower dosages, to treat hirsutism and, in combination with a GnRH analogue, male-limited precocious puberty. [25] In any case, the risk of hepatotoxicity with ketoconazole limits its use in all of these indications, especially in those that are benign such as hirsutism.
Oral ketoconazole has side effects too. In 2016, the FDA (U.S. Food and Drug Administration) limited the use of Nizoral oral tablets due to a potential risk of liver and adrenal damage. In some ...
Ivermectin may interact with cyclosporine, ketoconazole, erythromycin, and other medications used for dogs. Photo by bradleyhebdon, Canva Possible Ivermectin Contraindications
The FP receptor agonist, bimatoprost, in the form of an 0.03% ophthalmic solution termed Latisse, is approved by the US Food and Drug Administration to treat hypotrichosis of the eyelashes, in particular to darken and lengthen eyelashes for cosmetic purposes. [59] Also, bimatoprost may be used to treat small or underdeveloped eyelashes. [60] [61]
have known hypersensitivity to other azole medicines such as ketoconazole; [2] are taking terfenadine, if 400 mg per day multidose of fluconazole is administered; [2] concomitant administration of fluconazole and quinidine, especially when fluconazole is administered in high dosages; take SSRIs such as fluoxetine or sertraline.
Ketoconazole, a drug used to treat certain fungal infections. When nitrate-containing drugs or alpha-blockers are used with sildenafil, they can cause a sudden and severe drop in your blood ...
There are also many drug interactions. Patients must read in detail the enclosed data sheet(s) of any medicine. For example, the azole antifungals such as ketoconazole or itraconazole can be both substrates and inhibitors of the P-glycoprotein, which (among other functions) excretes toxins and drugs into the intestines. [34]
[3] [6] In addition to its increased potency, the drug is 12-fold less potent than racemic ketoconazole in inhibiting CYP7A1 (cholesterol 7α-hydroxylase), theoretically resulting in further reduced interference with bile acid production and metabolite elimination and therefore less risk of hepatotoxicity. [6]