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[3] [8] Serious side effects may include anaphylaxis, liver problems, confusion, and seizures. [4] Use is not recommended in pregnancy and breastfeeding. [3] [4] Because of the risk of injury, skeletal muscle relaxants should generally be avoided in geriatric patients. [3] Methocarbamol is a centrally acting muscle relaxant. [3]
Effectiveness has not been clearly shown for metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene. [7] Applicable conditions include acute back [8] or neck pain, or pain after an injury. Long-term use of muscle relaxants in such cases is poorly supported. [8]
Most sources still use the term "centrally acting muscle relaxant". According to MeSH, dantrolene is usually classified as a centrally acting muscle relaxant. [9] The World Health Organization, in its ATC, uses the term "centrally acting agents", [10] but adds a distinct category of "directly acting agents", for dantrolene. [11]
Eperisone hydrochloride is available as the brand name preparations Myonal and Epry as 50 mg sugar-coated tablets, or as 10% granules for oral administration. [6] An experimental form of the drug, as a transdermal patch system, has shown promising results in laboratory tests on rodents; however, this product is not currently available for human use.
Its use could be beneficial when adjusted for the addictive risk of opioids, especially on limited and controlled use of metamizole. [55] A 2019 Israeli conference also justified the approved status as a preventive to opioid dependence, and metamizole being safer than most analgesics for renal impaired patients.
In general, large-scale studies do tend to show that long-term use of antidepressants is associated with weight gain side effects. However, study data on escitalopram and weight changes is very ...
Long-term use may increase the risk of both cognitive and physical decline. [14] [15] It is unclear whether they affect the risk of death generally. [14] However, in older adults they do appear to increase the risk of death. [16] Possible effects of anticholinergics include:
More research is needed on Ozempic long-term side effects. Some severe side effects with long-term consequences may include pancreatitis, acute kidney injury, gallstones, gallbladder disease ...