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An example of a proton pump that is not electrogenic, is the proton/potassium pump of the gastric mucosa which catalyzes a balanced exchange of protons and potassium ions. [ citation needed ] The combined transmembrane gradient of protons and charges created by proton pumps is called an electrochemical gradient .
To be specific, the protein is a part of the P-type ATPase family. The systematic name of this enzyme class is ATP phosphohydrolase (H +-exporting). H +-exporting ATPase is also known as proton ATPase or more simply proton pump. Other names in common use include proton-translocating ATPase, yeast plasma membrane H +-ATPase, plant plasma ...
The gastric hydrogen potassium ATPase or H + /K + ATPase is the proton pump of the stomach.It exchanges potassium from the intestinal lumen with cytoplasmic hydronium [2] and is the enzyme primarily responsible for the acidification of the stomach contents and the activation of the digestive enzyme pepsin [3] (see gastric acid).
In most cases the proton-motive force is generated by an electron transport chain which acts as a proton pump, using the Gibbs free energy of redox reactions to pump protons (hydrogen ions) out across the membrane, separating the charge across the membrane. In mitochondria, energy released by the electron transport chain is used to move protons ...
The result is the disappearance of a proton from the cytoplasm and the appearance of a proton in the periplasm. Mitochondrial Complex III is this second type of proton pump, which is mediated by a quinone (the Q cycle). Some dehydrogenases are proton pumps, while others are not. Most oxidases and reductases are proton pumps, but some are not.
Proton ATPase, graphic representation. In the field of enzymology, a proton ATPase, or H +-ATPase, is an enzyme that catalyzes the following chemical reaction: ATP + H 2 O + H + in ADP + phosphate + H + out. The 3 substrates of this enzyme are ATP, H 2 O, and H +, whereas its 3 products are ADP, phosphate, and H +.
This page was last edited on 12 June 2006, at 16:09 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may ...
Proton pump inhibitors are prodrugs and their actual inhibitory form is somewhat controversial. In acidic solution, the sulfenic acid is isolated before reaction with one or more cysteines accessible from the luminar surface of the enzyme, a tetracyclic sulfenamide. This is a planar molecule thus any enantiomer of a PPI loses stereospecifity ...