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Varenicline. Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation [5][7] and for the treatment of dry eye disease. [6][8] It is a nicotinic acetylcholine receptor partial agonist. [5][6] When activated, this receptor releases dopamine in the nucleus accumbens, the brain's reward ...
Apomorphine. Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non- selective dopamine agonist which activates both D 2 -like and, to a much lesser extent, D 1 -like receptors. [2] It also acts as an antagonist of 5-HT 2 and α-adrenergic receptors with high affinity.
Cytisine. Cytisine, also known as baptitoxine, cytisinicline, or sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation. [1] However, it has been found effective in several randomized clinical trials, including some ...
Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. [6]
After 670 days, there were 1,172 new diagnoses of dementia among the study participants. When compared with people who took DPP-4 inhibitors, those who took SGLT-2 inhibitors had a 35 percent ...
Nicotinic agonist. A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine. Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine. [1]
Hydromorphone is a semi-synthetic μ-opioid agonist. As a hydrogenated ketone of morphine, it shares the pharmacologic properties typical of opioid analgesics. Hydromorphone and related opioids produce their major effects on the central nervous system and gastrointestinal tract.
A new study finds that weight loss drugs Like Ozempic could trigger bone loss. Doctors explain why, and how to protect yourself if you take one of these drugs.