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Cohort of 80 Breast Cancer Samples HRDetect was tested in 80 breast cancer cases with mainly ER positive and HER2 negative. The tool was able to find ones that exceed HRDetect score 0.7, including one germline BRCA1 mutation carrier, four germline BRCA2 mutation carriers and one somatic BRCA2 mutation carrier.
Breast cancers typically fall into one of four subtypes, based on whether the cancer cells have an overabundance of the HER2 gene, and/or receptors for estrogen (ER-positive), progesterone (PR ...
Breast cancer screening is the medical screening of asymptomatic, apparently healthy women for breast cancer in an attempt to achieve an earlier diagnosis. The assumption is that early detection will improve outcomes. A number of screening tests have been employed, including clinical and self breast exams, mammography, genetic screening ...
A predictive marker is a particular protein or gene that indicates sensitivity or resistance to a specific therapy. The use of predictive markers is becoming increasingly relevant in cancer therapy as it allows for better identification of patients who will respond positively to the therapy. In the clinical setting, predictive markers are ...
A breast cancer risk assessment tool uses a statistical model to estimate a woman’s risk of developing breast cancer over the next five years as well as over her lifetime, or up to about age 90 ...
The Nottingham prognostic index (NPI) is used to determine prognosis following surgery for breast cancer. [1][2] Its value is calculated using three pathological criteria: the size of the tumour; the number of involved lymph nodes; and the grade of the tumour. [1] It is calculated to select patients for adjuvant treatment.
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