Search results
Results From The WOW.Com Content Network
Treating chronic bacterial prostatitis requires prolonged therapy with an antibiotic that penetrates the prostate (ie, one with high lipid solubility, a low degree of ionization, high dissociation constant, low protein binding, and small molecular size).
Management of acute bacterial prostatitis (ABP) involves both choosing appropriate spectrum antibiotics that have good prostate tissue penetration and managing the complications and sequelae of the disease.
Good to excellent penetration into prostatic fluid and tis- sue has been demonstrated with many antimicrobial agents, including tobramycin, netilmicin, tetracyclines,
Treating CBP is challenging, because only few oral antibiotics could penetrate the prostate and achieve sufficient effective bactericidal concentration at the field of infection (Lipsky et al., 2010; Karaiskos et al., 2019).
Antibiotic penetration initially may be improved due to prostate inflammation during the acute infection; however, as the infection responds to therapy and the inflammation subsides, the antibiotic will have a more difficult time penetrating into the gland and achieving adequate drug levels.
Significant inflammation of the prostate allows for adequate penetration of most antimicrobials into prostate tissue. Empiric therapy depends on local antibiotic susceptibility patterns and severity of clinical illness, with intravenous antibiotics favored in acutely unwell patients.
Fluoroquinolones have the best penetration into prostatic tissue of all currently available antibiotic classes of drugs. Since these drugs exist in their zwitterion form with a pKa in both acidic and alkaline environments, these drugs penetrate and achieve prostatic fluid levels that are similar to those in plasma with ratios ranging from 0.12 ...
Treatment of chronic bacterial prostatitis includes a prolonged course (at least 3 to 6 weeks) of oral antibiotics that penetrate the alkaline environment of the chronically infected prostate.
Azithromycin, a macrolide antibiotic, has reported eradication rates of around 80%. It has good penetration into the prostate and is active against gram-positive bacteria and Chlamydia. It...
Significant inflammation of the prostate allows for adequate penetration of most antimicrobials into prostate tissue. Empiric therapy depends on local antibiotic susceptibility patterns and severity of clinical illness, with intravenous antibiotics favored in acutely unwell patients.