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Phosphodiesterase enzymes have been shown to be different in different types of cells, including normal and leukemic lymphocytes [11] and are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties.
This is the pronunciation key for IPA transcriptions of Spanish on Wikipedia. It provides a set of symbols to represent the pronunciation of Spanish in Wikipedia articles, and example words that illustrate the sounds that correspond to them.
Phosphodiesterase, enzyme important in intracellular communication; Pug dog encephalitis; ... The European Democratic Party (esp. in Spanish, French or Italian languages)
Ortografía de la lengua española (2010). Spanish orthography is the orthography used in the Spanish language.The alphabet uses the Latin script.The spelling is fairly phonemic, especially in comparison to more opaque orthographies like English, having a relatively consistent mapping of graphemes to phonemes; in other words, the pronunciation of a given Spanish-language word can largely be ...
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene. [ 5 ] [ 6 ] Various cellular responses are regulated by the second messengers cAMP and cGMP .
PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation mechanism. Most of the PDE families are composed of more than one gene.
The phosphodiesterase 1 isoenzyme family (along with the phosphodiesterase 4 family) is the most diverse one and includes numerous splice variant PDE1 isoforms. It has three subtypes, PDE1A, PDE1B and PDE1C which divide further into various isoforms. [1] [2]
A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquitous presence of this ...