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Since absolute aggregation rates are difficult to measure, one often refers to the dimensionless stability ratio W, defined as = where k fast is the aggregation rate coefficient in the fast regime, and k the coefficient at the conditions of interest. The stability ratio is close to unity in the fast regime, increases in the slow regime, and ...
In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly. [1] [2] Protein aggregates have been implicated in a wide variety of diseases known as amyloidoses, including ALS, Alzheimer's, Parkinson's and prion ...
Coacervate droplets dispersed in a dilute phase. Coacervate (/ k oʊ ə ˈ s ɜːr v ə t / or / k oʊ ˈ æ s ər v eɪ t /) is an aqueous phase rich in macromolecules such as synthetic polymers, proteins or nucleic acids.
To understand the formation and properties of such dispersions (incl emulsions), it must be considered that the dispersed phase exhibits a "surface", which is covered ("wet") by a different "surface" that, hence, are forming an interface (chemistry). Both surfaces have to be created (which requires a huge amount of energy), and the interfacial ...
Flocculation (except in polymer science) Process of contact and adhesion whereby dispersed molecules or particles are held together by weak physical interactions ultimately leading to phase separation by the formation of precipitates of larger than colloidal size.
The accumulation of platelets to the site of a wound to form a platelet plug or a thrombus; Flocculation, a process where a solute comes out of solution in the form of floccules or flakes; Overdispersion or statistical aggregation, where the variance of a distribution is higher than which we expect. Aggregation pheromone
In materials science, segregation is the enrichment of atoms, ions, or molecules at a microscopic region in a materials system. While the terms segregation and adsorption are essentially synonymous, in practice, segregation is often used to describe the partitioning of molecular constituents to defects from solid solutions, [1] whereas adsorption is generally used to describe such partitioning ...
To date, 37 human proteins have been found to form amyloid in pathology and be associated with well-defined diseases. [2] The International Society of Amyloidosis classifies amyloid fibrils and their associated diseases based upon associated proteins (for example ATTR is the group of diseases and associated fibrils formed by TTR). [3]