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The rare disease hardens the skin and internal organs of young women of child-bearing age causing disfigurement, and is potentially fatal. [5] In reaction to the lack of awareness of the disease in the medical community, she went on to found the Scleroderma Research Foundation in 1987, [2] an organization dedicated to finding a cure. [4]
The Juvenile Scleroderma Network is an organization dedicated to providing emotional support and educational information to parents and their children living with juvenile scleroderma, supporting pediatric research to identify the cause of and the cure for juvenile scleroderma, and enhancing public awareness.
Scleroderma in pregnancy is a complex situation; it increases the risk to both mother and child. [49] Overall, scleroderma is associated with reduced fetal weight for gestational age. [ 49 ] The treatment for scleroderma often includes known teratogens such as cyclophosphamide, methotrexate, mycophenolate , etc., so careful avoidance of such ...
In women, it includes structures such as ovaries, fallopian tubes, a uterus, and a vagina, while in men, it includes testes, vas deferens, seminal vesicles, prostate, and the penis. Autoimmune diseases of the reproductive system can affect both male and female fertility and reproductive health.
Morphea is a form of scleroderma that is more common in women than men, in a ratio 3:1. [17] Morphea occurs in childhood as well as in adult life. [3] Morphea is an uncommon condition that is thought to affect 2 to 4 in 100,000 people. [18] Adequate studies on the incidence and prevalence have not been performed.
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc), is a multisystem connective tissue disorder.The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia.
Women appear to generally mount larger inflammatory responses than men when their immune systems are triggered, increasing the risk of autoimmunity. Involvement of sex steroids is indicated by that many autoimmune diseases tend to fluctuate in accordance with hormonal changes, for example: during pregnancy, in the menstrual cycle, or when using ...
In 1999 a study noted, "In recent years there has been growing concern regarding the diagnosis of incomplete forms of the autoimmune diseases" [26] and the first classification criteria were proposed in that year. [1] Historically the condition was sometimes called undifferentiated connective tissue syndrome, latent lupus or incomplete lupus. [1]