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Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways.
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
G q/11/14/15 proteins all activate beta-type phospholipase C (PLC-β) to signal through calcium and PKC signaling pathways. [4] PLC-β then cleaves a specific plasma membrane phospholipid, phosphatidylinositol 4,5-bisphosphate (PIP 2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP 3).
Calcium signaling is the use of calcium ions (Ca 2+) to communicate and drive intracellular processes often as a step in signal transduction. Ca 2+ is important for cellular signalling , for once it enters the cytosol of the cytoplasm it exerts allosteric regulatory effects on many enzymes and proteins .
Phosphoinositide phospholipase C (PLC, EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase; systematic name 1-phosphatidyl-1D-myo-inositol-4,5 ...
Upon receptor stimulation with agonist, Gα q and β-γ subunits dissociate to initiate downstream effector pathways. Gα q stimulates phospholipase C (PLC) activity, which subsequently promotes the release of diacylglycerol (DAG) and inositol triphosphate (IP3), which in turn stimulate protein kinase C (PKC) activity and Ca 2+ release. [14]
5335 18803 Ensembl ENSG00000124181 ENSMUSG00000016933 UniProt P19174 Q62077 RefSeq (mRNA) NM_002660 NM_182811 NM_021280 RefSeq (protein) NP_002651 NP_877963 NP_067255 Location (UCSC) Chr 20: 41.14 – 41.2 Mb Chr 2: 160.57 – 160.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholipase C, gamma 1, also known as PLCG1 and PLCgamma1, is a protein that in humans involved in ...
PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.