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In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
18750 Ensembl ENSG00000154229 ENSMUSG00000050965 UniProt P17252 P20444 RefSeq (mRNA) NM_002737 NM_011101 RefSeq (protein) NP_002728 NP_035231 Location (UCSC) Chr 17: 66.3 – 66.81 Mb Chr 11: 107.82 – 108.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Function Protein kinase C (PKC) is a ...
Above is a ball-and-stick model of the inorganic phosphate molecule (H PO 4 2−).Colour coding: P (orange); O (red); H (white). The chemical activity of a protein kinase involves removing a phosphate group from ATP and covalently attaching it to one of three amino acids that have a free hydroxyl group.
From the titration of protonatable group, one can read the so-called pK a 1 ⁄ 2 which is equal to the pH value where the group is half-protonated (i.e. when 50% such groups would be protonated). The pK a 1 ⁄ 2 is equal to the Henderson–Hasselbalch pK a (pK HH a) if the titration curve follows the Henderson–Hasselbalch equation. [14]
The two mouse ROCK isoforms, ROCK1 and ROCK2, have high homology.They have 65% amino acid sequences in common and 92% homology within their kinase domains. [1] [4]ROCKs are homologous to other metazoan kinases such as myotonic dystrophy kinase (), DMPK-related cell division control protein 42 ()-binding kinases (MRCK) and citron kinase.
18754 Ensembl ENSG00000171132 ENSMUSG00000045038 UniProt Q02156 P16054 RefSeq (mRNA) NM_005400 NM_011104 RefSeq (protein) NP_005391 NP_035234 Location (UCSC) Chr 2: 45.65 – 46.19 Mb Chr 17: 86.48 – 86.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large ...
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. [6] PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.