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Warthin's tumor, also known as papillary cystadenoma lymphomatosum, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and germinal centers (lymph node-like stroma). It is named for pathologist Aldred Scott Warthin , who described two cases in 1929.
Malignant transformation is the process by which cells acquire the properties of cancer. This may occur as a primary process in normal tissue, or secondarily as malignant degeneration of a previously existing benign tumor .
Most salivary gland tumors are benign – that is, they are not cancer and will not spread to other parts of the body. These tumors are almost never life-threatening. There are many types of benign salivary gland tumors, with names such as adenomas, oncocytomas, Warthin tumors, and benign mixed tumors (also known as pleomorphic adenomas).
Malignant tumors are cancerous and can spread to other parts of the body. “When a doctor tells you that you have a tumor, he is not telling you that you have cancer. He is saying that there is a ...
Cytopathology of Warthin's tumor, with typical cellular features (and a relatively uncommon binucleated cell). [1] Pap stain. The relatively large size of the oncocytes is seen when comparing to the lymphocyte. Micrograph showing apocrine-type metaplasia of the breast with typical oncocytes. [2] H&E stain.
The tumor is not enveloped, but it is surrounded by a fibrous pseudocapsule of varying thickness. The tumor extends through normal glandular parenchyma in the form of finger-like pseudopodia, but this is not a sign of malignant transformation. The tumor often displays characteristic chromosomal translocations between chromosomes #3 and #8.
An salivary gland oncocytoma (also known as an oxyphilic adenoma) is a well-circumscribed, benign neoplastic growth comprising about one percent of all salivary gland tumors. The histopathology is marked by sheets of large, swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei.
Adenolymphoma of the parotid gland, or papillary cystadenoma lymphomatosum, is better known as "Warthin's tumor"; he described two cases in 1929. [18] [19] One of the pulmonary signs of pericarditis is named "Warthin's sound". [1] The Warthin-Starry stain, a silver-based stain for spirochetes, is named for him. [20] [21]