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A psychoactive drug, mind-altering drug, or consciousness-altering drug is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior. [1] The term psychotropic drug is often used interchangeably, while some sources present narrower definitions.
Synthetic cannabinoids are particularly useful in experiments to determine the relationship between the structure and activity of cannabinoid compounds, by making systematic, incremental modifications of cannabinoid molecules. [99] When synthetic cannabinoids are used recreationally, they present significant health dangers to users. [100]
“The cannabinoid system is widespread in the brain, so modulating cannabinoid function with products like THC could have a wide range of possible effects. We wanted to better understand which ...
There exist two primary CNS cannabinoid receptors, on which marijuana and the cannabinoids act. Both the CB 1 and CB 2 receptor are found in the brain. The CB 2 receptor is also found in the immune system. CB 1 is expressed at high densities in the basal ganglia, cerebellum, hippocampus, and cerebral cortex.
Δ-8-tetrahydrocannabinol (delta-8-THC, [a] Δ 8-THC) is a psychoactive cannabinoid found in the cannabis plant. [1] It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ 9-THC), the compound commonly known as THC, with which it co-occurs in hemp; natural quantities of ∆ 8-THC found in hemp are low.
The presence of these specialized cannabinoid receptors in the brain led researchers to the discovery of endocannabinoids, such as anandamide and 2-arachidonoyl glyceride . [citation needed] THC is a lipophilic molecule [27] and may bind non-specifically to a variety of entities in the brain and body, such as adipose tissue (fat).
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [ 1 ] [ 2 ] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis .
Cannabinol (CBN) is a mildly psychoactive phytocannabinoid that acts as a low affinity partial agonist at both CB 1 and CB 2 receptors.This activity at CB 1 and CB 2 receptors constitutes interaction of CBN with the endocannabinoid system (ECS).