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Synthetic cannabinoids are particularly useful in experiments to determine the relationship between the structure and activity of cannabinoid compounds, by making systematic, incremental modifications of cannabinoid molecules. [99] When synthetic cannabinoids are used recreationally, they present significant health dangers to users. [100]
3D model of 2-Arachidonoylglycerol, an endocannaboid. The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the central nervous system (including the brain) and peripheral nervous system.
“The cannabinoid system is widespread in the brain, so modulating cannabinoid function with products like THC could have a wide range of possible effects. We wanted to better understand which ...
Tetrahydrocannabinol (THC) is the main psychoactive component of cannabis, which is one of the 483 known compounds in the plant, including at least 65 other cannabinoids, such as cannabidiol (CBD). Cannabis can be used by smoking , vaporizing , within food , or as an extract .
There exist two primary CNS cannabinoid receptors, on which marijuana and the cannabinoids act. Both the CB 1 and CB 2 receptor are found in the brain. The CB 2 receptor is also found in the immune system. CB 1 is expressed at high densities in the basal ganglia, cerebellum, hippocampus, and cerebral cortex.
A psychoactive drug, mind-altering drug, or consciousness-altering drug is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior. [1] The term psychotropic drug is often used interchangeably, while some sources present narrower definitions.
The presence of these specialized cannabinoid receptors in the brain led researchers to the discovery of endocannabinoids, such as anandamide and 2-arachidonoyl glyceride . [citation needed] THC is a lipophilic molecule [27] and may bind non-specifically to a variety of entities in the brain and body, such as adipose tissue (fat).
The psychoactive effects of cannabis, known as a "high", are subjective and vary among persons and the method of use. When THC enters the blood stream and reaches the brain, it binds to cannabinoid receptors. The endogenous ligand of these receptors is anandamide, the effects of which THC emulates.