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Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach. [ 1 ]
Gastric acid or stomach acid is the acidic component – hydrochloric acid of gastric juice, produced by parietal cells in the gastric glands of the stomach lining. In humans, the pH is between one and three, much lower than most other animals, but is very similar to that of carrion eating carnivores , needing protection from ingesting pathogens .
Several types of endocrine cells are found in the gastric glands. The pyloric glands contain gastrin -producing cells ( G cells ); this hormone stimulates acid production from the parietal cells. Enterochromaffin-like cells (ECLs), found in the oxyntic glands release histamine , which also is a powerful stimulant of the acid secretion.
Mucus is released in the stomach and intestine, and serves to lubricate and protect the inner mucosa of the tract. It is composed of a specific family of glycoproteins termed mucins and is generally very viscous. Mucus is made by two types of specialized cells termed mucous cells in the stomach and goblet cells in the intestines. Signals for ...
These cells store and release histamine when the pH of the stomach becomes too high. The release of histamine is stimulated by the secretion of gastrin from the G cells. [1] Histamine promotes the production and release of HCL from the parietal cells to the blood and protons to the stomach lumen.
Intrinsic factor (IF), cobalamin binding intrinsic factor, [5] also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorption of vitamin B 12 later on in the distal ileum of the small intestine. [6]
Gastrin is a hormone produced by enteroendocrine G cells in the pyloric glands. [1] All three of these stimulate parietal cells to secrete hydrochloric acid and intrinsic factor. The chief cells secrete pepsinogen in response to gastrin and especially Ach, and ACh also stimulates mucus secretion. [1]
Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach.It is secreted into the bloodstream. The encoded polypeptide is preprogastrin, which is cleaved by enzymes in posttranslational modification to produce progastrin (an intermediate, inactive precursor) and then gastrin in various forms, primarily the following three: