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Müllerian agenesis, also known as Müllerian aplasia, vaginal agenesis, or Mayer–Rokitansky–Küster–Hauser syndrome (MRKH syndrome), is a congenital malformation characterized by a failure of the Müllerian ducts to develop, resulting in a missing uterus and variable degrees of vaginal hypoplasia of its upper portion.
Surgical intervention depends on the extent of the individual problem. With a didelphic uterus surgery is not usually recommended. A uterine septum can be resected in a simple out-patient procedure that combines laparoscopy and hysteroscopy. This procedure greatly decreases the rate of miscarriage for women with this anomaly. [citation needed]
Müllerian anomalies can be part of a multiple malformation syndrome. [1] [3] Studies have estimated that Mullerian anomalies can affect between 4 percent and nearly 7 percent of the female population. [4] [5] Müllerian anomalies occur as a congenital malformation of the Müllerian ducts during embryogenesis.
[10] [11] The condition occurs in males and consists of normal-functioning reproductive organs and gonads, but also female reproductive organs such as the uterus and the fallopian tubes. The fetus has two sets of tubes which give rise to accessory reproductive organs - the (Wolffian) mesonephric ducts and the (Müllerian) paramesonephric ducts ...
Management of vaginal agenesis: correction of vaginal agenesis in MRKH syndrome with creation of a functional neovagina has been a hallmark in the treatment. Various different surgical and non-surgical methods have been suggested for vaginal construction.
Generally, diseases outlined within the ICD-10 codes Q50-Q52 within Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities should be included in this category. Wikimedia Commons has media related to Congenital diseases and disorders of female genital organs .
Four types of uterine malformations. The uterus is formed during embryogenesis by the fusion of the two paramesonephric ducts (also called Müllerian ducts). This process usually fuses the two Müllerian ducts into a single uterine body but fails to take place in these affected women who maintain their double Müllerian systems.
A bicornuate uterus is an indication for increased surveillance of a pregnancy, though most women with a bicornuate uterus are able to have healthy pregnancies. [1] Women with a bicornuate uterus are at an increased risk of recurrent miscarriage, [2] [10] preterm birth, [2] [11] malpresentation, [2] [12] disruptions to fetal growth, [13] premature rupture of membranes, placenta previa and ...