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Dogs Once a day in right eye and orally 13 weeks 2.0% in eye, 7.5 mg/kg/day by mouth No mortality observed. Monkey Once a day in right eye 52 weeks 2.0% Mortalities observed. Rats Once a day orally 4 weeks 10 or 30 mg/kg/day in males and females Mortality observed at oral administration of 90 mg/kg/day.
C 18 H 36 N 4 O 10: 468.50 g·mol −1: Gentamicin A 1; Gentamicin A 2; 55715-66-7 CID 86489 from PubChem: C 17 H 33 N 3 O 11: 455.46 g·mol −1: Gentamicin A 3; 55715-67-8 CID 86490 from PubChem: C 18 H 36 N 4 O 10: 468.50 g·mol −1: Gentamicin A 4; Gentamicin B; Betamicin; 36889-15-3 CID 37569 from PubChem: C 19 H 38 N 4 O 10: 482.53 g ...
The veterinary uses of clindamycin are quite similar to its human indications, and include treatment of osteomyelitis, [74] skin infections, and toxoplasmosis, for which it is the preferred drug in dogs and cats. [75] They can be used both by mouth and topically. [62] A disadvantage is that bacterial resistance can develop fairly quickly. [62]
Upon the original patent expiration, Hi-Tech Pharma was the first of many generic competitors to submit an abbreviated new drug application (ANDA) for dorzolamide hydrochloride/timolol maleate eye drops. [19] Hi-Tech Pharma's ANDA was approved on 28 October 2008. At the time, controversy surrounded the approval of this first ANDA.
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. [5] This includes use as an eye ointment to treat conjunctivitis. [6] By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. [5]
A noted drug interaction involves erythromycin and simvastatin, resulting in increased simvastatin levels and the potential for rhabdomyolysis. Another group of CYP3A4 substrates are drugs used for migraine such as ergotamine and dihydroergotamine ; their adverse effects may be more pronounced if erythromycin is associated.
The drug safety communication also announced the required labeling updates to reflect this new safety information. [85] The FDA put out another label change in July 2017, strengthening the warnings about potentially disabling adverse effects and limiting use of these drugs to second-line treatments for acute sinusitis, acute bronchitis, and ...
Preservative-free eye drops are found in single vials. However, single unit-dose artificial tears without preservatives are more expensive than bottled artificial tears with preservatives. [9] Some patients confuse over the counter drops that contain tetrahydrozoline (i.e. Visine®), a vasoconstrictor, with artificial tears. [11]