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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
I 1 PP2A has a highly acidic C-terminal tail and the N-terminus is leucine/isoleucine rich (Li et al., 1996). In the presence of physiological conditions of Mn 2+, I 1 PP2A can also associate with and stimulate the activity of PP1 but Mn 2+ also does not affect the inhibition of PP2A through I 1 PP2A, in vitro (Janssens & Goris, 2001).
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism.Phosphorylation enables the activation or The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit.
A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (), with up to 30% of all proteins being phosphorylated at any given time.
PP2A is involved in multiple regulatory processes, such as DNA replication, metabolism, transcription, and development. PP2B, also called calcineurin , is involved in the proliferation of T cells ; because of this, it is the target of some drugs that seek to suppress the immune system.
5518 51792 Ensembl ENSG00000105568 ENSMUSG00000007564 UniProt P30153 Q76MZ3 RefSeq (mRNA) NM_014225 NM_001363656 NM_016891 RefSeq (protein) NP_055040 NP_001350585 NP_055040.2 NP_058587 Location (UCSC) Chr 19: 52.19 – 52.23 Mb Chr 17: 21.17 – 21.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is ...
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The molecular mechanisms underlying JS are unknown. Broadly, PP2A dysfunction is known to be associated with other pathologies such as Alzheimer's disease, Parkinson's disease, and cancer. [6] Studies of specific JS-causing variants such as E420K have implicated PI3K/AKT/mTOR pathway dysregulation in JS pathogenesis. [4]