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Clonazepam, sold under the brand name Klonopin among others, is a benzodiazepine medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, obsessive–compulsive disorder (OCD), and akathisia. [11]
The long-term effects of benzodiazepines are very similar to the long-term effects of alcohol consumption (apart from organ toxicity) and other sedative-hypnotics. Withdrawal effects and dependence are not identical. Dependence can be managed, with a medical professional of course, but withdrawal can be fatal.
They modulate the immune system and are involved in the body response to injury. [ 183 ] [ 184 ] Benzodiazepines also function as weak adenosine reuptake inhibitors . It has been suggested that some of their anticonvulsant, anxiolytic, and muscle relaxant effects may be in part mediated by this action. [ 185 ]
A study into the effects of the benzodiazepine receptor antagonist, flumazenil, on benzodiazepine withdrawal symptoms persisting after withdrawal was carried out by Lader and Morton. Study subjects had been benzodiazepine-free for between one month and five years, but all reported persisting withdrawal effects to varying degrees.
With most benzodiazepines, noticeable effects usually wear off within a few hours. Nevertheless, as long as the drug is present it will exert subtle effects within the body. These effects may become apparent during continued use or may appear as withdrawal symptoms when dosage is reduced or the drug is stopped. [citation needed]
Before and after photos of the deadly wildfires in the Los Angeles area have sent tens of thousands scrambling for safety and decimated neighborhoods.
A 2022 Novo Nordisk study looked at nearly 2,000 people with a body mass index (BMI) of 30 or higher or 27 or more with at least one weight-related health condition that wasn’t type 2 diabetes.
The use of benzodiazepines has a profound effect on almost every aspect of brain and body function, either directly or indirectly. [ 39 ] With chronic benzodiazepine use, tolerance develops rapidly to most of its effects, so that, when benzodiazepines are withdrawn, various neurotransmitter systems go into overdrive due to the lack of ...