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Once released, the histamine can react with local or widespread tissues through histamine receptors. [citation needed] Histamine, acting on H 1-receptors, produces pruritus, vasodilation, hypotension, flushing, headache, bradycardia, bronchoconstriction, increase in vascular permeability and potentiation of pain. [2]
Cluster headache is a neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye(s). [1] There is often accompanying eye watering, nasal congestion, or swelling around the eye on the affected side. [1]
The manifestations of histamine intolerance, or, adverse reactions to ingested histamine, are not confined to the gastrointestinal system, and are usually systemic, affecting the entire body; still, these symptoms are often sporadic and non-specific: [5] [6] [7] symptoms attributed to histamine intolerance are wide-ranging and may affect various physiological systems, including the skin ...
Hydroxyzine works by blocking the effects of histamine. [9] It is a first-generation antihistamine in the piperazine family of chemicals. [8] [4] Common side effects include sleepiness, headache, and dry mouth. [8] [9] Serious side effects may include QT prolongation. [9] It is unclear if use during pregnancy or breastfeeding is safe. [8]
Histamine therapy for treatment of multiple sclerosis is currently being studied. The different H receptors have been known to have different effects on the treatment of this disease. The H 1 and H 4 receptors, in one study, have been shown to be counterproductive in the treatment of MS.
Experts recommend seeking medical attention right away if you have a sudden, severe headache that feels like "the worst headache of your life," Mikhael says, or what the Mayo Clinic describes as a ...
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