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A depressogen is a substance that causes or can cause depression, usually as a side effect. [1] They are the functional opposites of antidepressants. [2]Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like ...
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
Dicamba is toxic to conifer species but is in general less toxic to grasses. [2] Dicamba is a synthetic auxin that functions by increasing plant growth rate, leading to senescence and cell death. [2] [11] The growth regulating properties of dicamba were first discovered by Zimmerman and Hitchcock in 1942. [12]
Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness, possibly leading to coma or death. It is the result of inhibited or suppressed brain activity .
Mostly in the frontal cortex, these differences often stem from a smaller brain volume, and the decreased blood flow that results influences the hypofrontality. [9] It has not been determined if the reduction of the frontal cortex is the ultimate cause of the symptoms, or if the condition worsens as the symptoms develop.
Cerebral circulation is the movement of blood through a network of cerebral arteries and veins supplying the brain. The rate of cerebral blood flow in an adult human is typically 750 milliliters per minute, or about 15% of cardiac output. Arteries deliver oxygenated blood, glucose and other nutrients to the brain.
Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater ...
[2] [4] As depression is also associated with pro-inflammatory responses, the suggestion is that the causes of depression are little different from the causes of the autoimmune diseases it is largely co-morbid with, with sanitary environments increasing the risk of excessive inflammation in response to psychosocial stressors just as it is ...