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Minoxidil is a medication used for the treatment of high blood pressure and pattern hair loss. [5] [6] [7] It is an antihypertensive and a vasodilator. [10]
Minoxidil sulfate, also known as minoxidil sulfate ester or minoxidil N-O-sulfate, is an active metabolite of minoxidil (Rogaine, Loniten, others) and is the active form of this agent. [ 1 ] [ 2 ] Minoxidil acts as a prodrug of minoxidil sulfate. [ 1 ]
Minoxidil, applied topically, is widely used for the treatment of hair loss. It may be effective in helping promote hair growth in both men and women with androgenic alopecia . [ 20 ] [ 21 ] About 40% of men experience hair regrowth after 3–6 months. [ 22 ]
Minoxidil (Rogaine) is a nonprescription medication approved for male pattern baldness and alopecia areata. In a liquid or foam, it is rubbed into the scalp twice a day. Some people have an allergic reaction to the propylene glycol in the minoxidil solution and a minoxidil foam was developed without propylene glycol. Not all users will regrow hair.
Pattern hair loss (also known as androgenetic alopecia (AGA) [1]) is a hair loss condition that primarily affects the top and front of the scalp. [2] [3] In male-pattern hair loss (MPHL), the hair loss typically presents itself as either a receding front hairline, loss of hair on the crown and vertex of the scalp, or a combination of both.
Minoxidil (brand name Rogaine®) is a non-prescription topical medication that promotes hair growth and regrowth by restarting the growth phase in dormant hair follicles.
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The SULT1A1 enzyme is expressed in outer roots sheath of hair follicles. Minoxidil, the only US FDA approved topical drug for re-growing hair in male and female pattern hair loss (androgenetic alopecia patients) is a pro-drug. Minoxidil is converted to its active form (minoxidil sulfate) by the hair sulfotransferase enzyme (SULT1A1). [6]