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Early-onset Alzheimer's disease (EOAD), also called younger-onset Alzheimer's disease (YOAD), [1] is Alzheimer's disease diagnosed before the age of 65. [2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases.
Early onset dementia or young onset dementia refers to dementia with symptom onset prior to age 65. This condition is a significant public health concern, as the number of individuals with early onset dementia is increasing worldwide.
Frontotemporal dementia (FTD) is an early onset disorder that mostly occurs between the ages of 45 and 65, [13] but can begin earlier, and in 20–25% of cases onset is later. [11] [14] Men and women appear to be equally affected. [15] It is the most common early presenting dementia. [16]
Parkinson's typically manifests in individuals over 60, with about one percent affected. In those younger than 50, it is termed "early-onset PD". No cure for Parkinson's is known, and treatment focuses on alleviating symptoms. Initial treatment typically includes L-DOPA, MAO-B inhibitors, or dopamine agonists.
There is early development of secondary sex characters and gametogenesis also starts earlier. Precocious puberty is of two types: true precocious puberty and pseudoprecocious puberty. In a minority of children with precocious puberty, the early development is triggered by a disease such as a tumor or injury of the brain. [1]
The age of onset is the age at which an individual acquires, develops, or first experiences a condition or symptoms of a disease or disorder. For instance, the general age of onset for the spinal disease scoliosis is "10-15 years old," [ 1 ] meaning that most people develop scoliosis when they are of age between ten and fifteen years.
The median onset interquartile range of substance use disorders is 18–27, while the median onset age is 20. The median onset age of mood disorders is 25. [63] Even disorders [64] that begin earlier, like schizophrenia spectrum diagnoses, can reveal themselves within the developmental stage of emerging adulthood.
Childhood schizophrenia manifests before the age of 13 and is also known as very early-onset schizophrenia. Onset before the age of 18 is known as early-onset schizophrenia, and is rare; very early-onset is even rarer with a frequency of 1 in 40,000. [50]