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Selenium disulfide, also known as selenium sulfide, is a chemical compound and medication used to treat seborrheic dermatitis, dandruff, and pityriasis versicolor. [ 1 ] [ 2 ] It is applied to the affected area as a lotion or shampoo. [ 3 ]
Selenium sulfide slows down epidermal proliferation. It is fungicidal to Pityrosporum ovale. It also acts as a keratolytic. Selenium sulfide is also known to reduce dryness of scalp and folliculitis. [2] Systemic toxicity can appear if it is applied to inflamed skin. Hypersensitivity reactions are noted in some people.
Systemic therapy with oral antifungals including itraconazole, fluconazole, ketoconazole is effective, but adverse side effects have been documented for fluconazole and ketoconazole, with the latter not recommended for use, while itraconazole, with its good safety profile, is the most commonly prescribed. [3]
Some inorganic selenide sulfide compounds are also known. Simplest is the material selenium sulfide, which has medicinal properties. It adopt the diverse structures of elemental sulfur but with some S atoms replaced by Se. Other inorganic selenide sulfide compounds occur as minerals and as pigments. One example is antimony selenosulfide.
Topical antifungal medications containing selenium sulfide are often recommended. [15] Ketoconazole (Nizoral ointment and shampoo) is another treatment. It is normally applied to dry skin and washed off after 20 minutes, repeated daily for two weeks.
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Selenium sulfide can refer to either of the following: Selenium disulfide, SeS 2; Selenium hexasulfide, Se 2 S 6 This page was last edited on 27 January ...