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aP2 (adipocyte Protein 2) [5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs [6] has the possibility of treating heart disease and the metabolic syndrome. [7]
The adipose differentiation related protein (ADRP) was first characterized as an mRNA molecule that express early in adipocyte differentiation. [8] The full length cDNA was cloned by rapid amplification of cDNA ends method and sequence analysis results in a protein with 425 amino acids that is unique and similar sequences had not previously been reported.
Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. [1] Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes and other cell types.
Adipocyte FABP (A-FABP): Located in adipose tissue, A-FABP plays a crucial role in lipid metabolism, including the storage and release of fatty acids in adipocytes. Intestinal FABP (I-FABP): Found in the intestine, I-FABP is essential for the absorption and transport of dietary fatty acids.
Examples of approved drugs that act as renal tubular transport inhibitors include: Probenecid: This is an inhibitor of the organic anion transport system, particularly OAT1 and OAT3. [2] [1] It is used clinically to increase the systemic concentrations of certain drugs by reducing their renal excretion. [4]
The main effect of expression and repression of specific genes is an increase in the storage of fatty acids in adipocytes, thereby decreasing the amount of fatty acids present in circulation. [3] As a result, cells become more dependent on the oxidation of carbohydrates , more specifically glucose , in order to yield energy for other cellular ...
The disulfide binding of the inhibitor takes place in the luminal sector of the H + /K + ATPase were 2 mol of inhibitor is bound per 1 mol of active site H + /K + ATPase. [19] [20] All PPIs react with cysteine 813 in the loop between TM5 and TM6 on the H + /K + ATPase, fixing the enzyme in the E2 configuration. Omeprazole reacts with cysteine ...
1244 12780 Ensembl ENSG00000023839 ENSMUSG00000025194 UniProt Q92887 Q8VI47 RefSeq (mRNA) NM_000392 NM_013806 RefSeq (protein) NP_000383 NP_038834 Location (UCSC) Chr 10: 99.78 – 99.85 Mb Chr 19: 43.77 – 43.83 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT ...