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IL-12 binds to the IL-12 receptor, which is a heterodimeric receptor formed by IL-12Rβ1 and IL-12Rβ2. [6] IL-12Rβ2 is considered to play a key role in IL-12 function, since it is found on activated T cells and is stimulated by cytokines that promote Th1 cells development and inhibited by those that promote Th2 cells development.
Interleukin-7 receptor-α deficiency; ... (TTC7A deficiency) Hepatic venoocclusive disease with immunodeficiency ... Interleukin 12 receptor, beta 1 deficiency;
Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, Measles virus , and Human ...
Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1 , is the name of its human gene . [ 5 ] IL-12Rβ1 is also known as CD212 ( cluster of differentiation 212).
Specifically, Interleukin 2 and Interleukin 7 are responsible for T-cell proliferation and survival. [12] Likewise, the action of Interleukin 4 and Interleukin 15 will lead to proliferation and differentiation of B-cells into antibody secreting plasma cells. [12] Lastly, Interleukin 15 helps generate developed and matured natural killer cells. [5]
Interleukin-1 receptor-associated kinase deficiency is an inherited disorder of the immune system. [6] This immunodeficiency leads to recurrent infections caused by the pyogenic bacteria, for example Streptococcus pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa, but not by other infectious agents.
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare genetic disease. It is a primary immunodeficiency featured by molecular defects in IL12 / IFNγ dependent signalling pathway, leading to increased susceptibility to local or disseminated infections by environmental mycobacteria , Mycobacterium bovis Bacille Calmette-Guerin ...
Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) [5] is a protein subunit that in humans is encoded by the IL12B gene. IL-12B is a common subunit of interleukin 12 and interleukin 23.