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Cocaine dependence is a neurological disorder that is characterized by withdrawal symptoms upon cessation from cocaine use. [1] It also often coincides with cocaine addiction which is a biopsychosocial disorder characterized by persistent use of cocaine and/or crack despite substantial harm and adverse consequences.
When substituted amphetamines are used, drug tolerance develops rapidly. [8] Amphetamine dependence has shown to have the highest remission rate compared to cannabis, cocaine, and opioids. [9] Severe withdrawal associated with dependence from recreational substituted amphetamine use can be difficult for a user to cope with.
Stimulant use disorder is a type of substance use disorder where the use of stimulants caused clinically significant impairment or distress. It is defined in the DSM-5 as "the continued use of amphetamine-type substances, cocaine, or other stimulants leading to clinically significant impairment or distress, from mild to severe". [1]
Reverse tolerance can also occur in users of stimulants such as cocaine or amphetamines. A previously recreational dose may become enough to cause psychosis in regular users, or users who previously had a psychotic episode may be more likely to have one in the future and at lower doses once drug usage continues. [6]
Substance-related disorders, also known as substance use disorders, are a type of mental disorder that affects a person's brain and behavior, leading to their inability to control their use of substances like legal or illegal drugs, alcohol, or medications. The disorders can lead to large societal problems.
Alcohol and cocaine (for example coca wine) increase cardiovascular toxicity; [10] alcohol or depressant drugs, when taken with opioids, lead to an increased risk of overdose; Opioids or cocaine taken with ecstasy or amphetamines also result in additional acute toxicity. [11]