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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
Advanced Placement (AP) Biology (also known as AP Bio) is an Advanced Placement biology course and exam offered by the College Board in the United States. For the 2012–2013 school year, the College Board unveiled a new curriculum with a greater focus on "scientific practices". [1]
The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
They are often found in signal transduction proteins. PTB-domain binding specificity is determined by residues to the amino-terminal side of the phosphotyrosine. Examples: the PTB domains of both SHC and IRS-1 bind to a NPXpY sequence. PTB-containing proteins such as SHC and IRS-1 are important for insulin responses of human cells.
Phosducin-transducin beta-gamma complex. Beta and gamma subunits of G-protein are shown by blue and red, respectively. Guanosine diphosphate Guanosine triphosphate. G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
Open Library is an online project intended to create "one web page for every book ever published". Created by Aaron Swartz, [3] [4] Brewster Kahle, [5] Alexis Rossi, [6] Anand Chitipothu, [6] and Rebecca Hargrave Malamud, [6] Open Library is a project of the Internet Archive, a nonprofit organization.
Principles of Biology is a college level biology electronic textbook published by Nature Publishing in 2011. The book is not a digitally reformatted version of a paper book. [ 1 ] The book, the first in a projected series, is Nature Publishing's first foray into textbook publishing.
Jobs's holdings in Disney far exceeded those of Eisner, who holds 1.7%, and of Disney family member Roy E. Disney, who until his 2009 death held about 1% of the company's stock and whose criticisms of Eisner—especially that he soured Disney's relationship with Pixar—accelerated Eisner's ousting. Upon completion of the merger, Jobs received ...