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A related alternative suggests that a globular oligomer localized to dendritic processes and axons in neurons is the cytotoxic species. [43] [44] The prefibrillar aggregates were shown to be able to disrupt the membrane. [45] The cytotoxic-fibril hypothesis presents a clear target for drug development: inhibit the fibrillization process.
The nervous and endocrine systems often act together in a process called neuroendocrine integration, to regulate the physiological processes of the human body. Neuroendocrinology arose from the recognition that the brain, especially the hypothalamus , controls secretion of pituitary gland hormones, and has subsequently expanded to investigate ...
Age-related neuropathologies such as Alzheimer's disease, Parkinson's disease, diabetes, hypertension and arteriosclerosis make it difficult to distinguish the normal patterns of aging. [ 18 ] [ 19 ] One of the important differences between normal aging and pathological aging is the location of neurofibrillary tangles.
But in people with dementia—which is an umbrella term for mental decline and can be related to a number of diseases such as Alzheimer's—there’s a phenomenon known as “sundowning,” where ...
[5] [6] One class of stress hormone responsible for negatively affecting long-term, delayed recall memory is the glucocorticoids (GCs), the most notable of which is cortisol. [1] [6] [7] Glucocorticoids facilitate and impair the actions of stress in the brain memory process. [8] Cortisol is a known biomarker for stress. [9]
Human growth hormone derived from cadavers was linked to Alzheimer's disease in five patients who received injections decades ago, a study in Nature Medicine finds. ... They developed dementia ...
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