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The pituitary produces multiple hormones relating to various metabolic functions. Sufficiently low production of certain pituitary hormones can be fatal resulting in the failure of the thyroid or adrenal glands. [citation needed] Common symptoms include nausea, vomiting, fatigue, loss of libido, amenorrhea, and dizziness. [1]
[1] [10] Should any affected organs show chronic inflammatory infiltrate ( lymphocytes ), this would be an indication. Moreover, autoantibodies reacting to specific antigens is common, in the immune system of an affected individual.
With appropriate treatment, the overall outcome is generally favorable, [10] and most people are able to lead a reasonably normal life. [11] Without treatment, an adrenal crisis can result in death. [1] Addison's disease affects about 9 to 14 per 100,000 people in the developed world. [1] [3] It occurs most frequently in middle-aged females. [1]
Addison's disease, or primary adrenal insufficiency, is an uncommon chronic illness characterized by insufficient production of cortisol and aldosterone by the adrenal glands. [17] Chronic primary adrenal insufficiency is typically characterized by an extended period of malaise, fatigue, anorexia, weight loss, joint and back pain, and skin ...
The fatigue must have lasted for 6 months or longer, and be present at least 50% of the time; Other symptoms are possible, such as muscle pain, mood problems, or sleep disturbance; Conditions known to cause severe fatigue and some mental conditions exclude a diagnosis. Post-infectious fatigue syndrome also requires evidence of a prior infection ...
Several cytokines have been also shown to interfere with the HPA axis at multiple levels. [10] There is also an increase in the number and affinity of glucocorticoid receptors. [ 6 ] Levels of corticosteroid-binding globulin (CBG) and albumin , which normally bind cortisol, are decreased, resulting in increased levels of free cortisol. [ 9 ]
Adrenal fatigue or hypoadrenia is a pseudo-scientific term used by alternative medicine providers to suggest that the adrenal glands are exhausted and unable to produce adequate quantities of hormones, primarily cortisol, due to chronic stress or infections. [1]
Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones.The adrenal glands—also referred to as the adrenal cortex—normally secrete glucocorticoids (primarily cortisol), mineralocorticoids (primarily aldosterone), and androgens.