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Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the (enzyme's) active site. [1] They are found ubiquitously in both eukaryotes and prokaryotes. Serine proteases fall into two broad categories based on their structure: chymotrypsin-like (trypsin-like ...
Kexin (EC 3.4.21.61) is a prohormone-processing protease, specifically a yeast serine peptidase, [1] found in the budding yeast (S. cerevisiae). It catalyzes the cleavage of -Lys-Arg- and -Arg-Arg- bonds to process yeast alpha-factor pheromone and killer toxin precursors. The human homolog is PCSK4. It is a family of subtilisin-like peptidases.
Hepsin is a cell surface serine protease. [6]Hepson contains a peptidase S1 domain and an SRCR domain. The SRCR domain is located in the extracellular part of the protein, it is formed primarily by three elements of regular secondary structure: a 12-residue alpha helix, a twisted five-stranded antiparallel beta sheet, and a second, two-stranded, antiparallel sheet.
Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. [5] [6] The HTRA1 protein is composed of four distinct protein domains.They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain.
69453 Ensembl ENSG00000237412 ENSMUSG00000036480 UniProt P0CW18 F2YMG0 RefSeq (mRNA) NM_001195129 NM_001369848 NM_027084 RefSeq (protein) NP_001182058 NP_001356777 NP_081360 Location (UCSC) Chr 2: 232.52 – 232.53 Mb Chr 1: 87.11 – 87.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Putative Serine Protease 56 (PRSS56) is a serine protease that in humans is encoded by the PRSS56 ...
Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death (apoptosis) in the target cell, thus eliminating cells that have become cancerous or are infected with viruses or bacteria. [1] Granzymes also kill bacteria [2] and inhibit viral replication.
70835 Ensembl ENSG00000005001 ENSG00000282937 ENSMUSG00000045027 UniProt Q9GZN4 Q9ER10 RefSeq (mRNA) NM_022119 NM_133731 RefSeq (protein) NP_071402 NP_598492 Location (UCSC) Chr 16: 2.85 – 2.86 Mb Chr 17: 24.21 – 24.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that ...
Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8).