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Pedicels interdigitate, thereby giving rise to thin gaps called filtration slits. [3] The slits are covered by slit diaphragms which are composed of a number of cell-surface proteins including nephrin , podocalyxin , and P-cadherin , which restrict the passage of large macromolecules such as serum albumin and gamma globulin and ensure that they ...
The renal hilum or renal pedicle is the recessed central fissure of the kidney where its vessels, nerves and ureter pass. The medial border of the kidney is concave in the center and convex toward either extremity; it is directed forward and a little downward.
These pedicels interdigitate with pedicels of adjacent podocytes forming filtration slits. There are two poles in the renal corpuscle, a vascular pole and a tubular pole . [ 4 ] The vascular pole is a location of the glomerulus.
The podocyte is a highly specialised epithelial cell in Bowman's capsule in the kidney. Primary processes of the podocytes form terminal foot processes. The podocyte foot processes wrap around the glomerular capillaries in the kidney to function in the filtration barrier.
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The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
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A partial nephrectomy should be attempted when there is a kidney tumor in a solitary kidney, when there are kidney tumors in both kidneys, or when removing the entire kidney could result in kidney failure and the need for dialysis. Partial nephrectomy is also the standard of care for nearly all patients with small renal masses (<4 cm in size). [22]