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Unlike HUS and aHUS, [39] [40] TTP is known to be caused by a defect in the ADAMTS13 protein, [41] so a lab test showing ≤5% of normal ADAMTS13 levels is indicative of TTP. [28] ADAMTS13 levels above 5%, coupled with a positive test for shiga-toxin / enterohemorrhagic E. coli (EHEC), are more likely indicative of HUS, [ 42 ] whereas absence ...
Platelet concentrations vary between individuals and over time, with the population average between 250,000 and 260,000 cells per mm 3 (equivalent to per microliter), but the typical laboratory accepted normal range is between 150,000 and 400,000 cells per mm 3 or 150–400 × 10 9 per liter.
Thrombosis (from Ancient Greek θρόμβωσις (thrómbōsis) ' clotting ') is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. ...
Giant platelet disorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelets cannot stick adequately to injured blood vessel walls, resulting in abnormal bleeding when injured.