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Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical use has been established as anti- glaucoma agents, diuretics , antiepileptics , in the management of mountain sickness , gastric and duodenal ulcers , idiopathic intracranial hypertension , neurological disorders , or ...
For example, carbonic anhydrase produces acid in the stomach lining. In the kidney, the control of bicarbonate ions influences the water content of the cell. The control of bicarbonate ions also influences the water content in the eyes. Inhibitors of carbonic anhydrase are used to treat glaucoma, the excessive build-up of water in the eyes.
It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humor. [3] Dorzolamide was approved for medical use in the United States in 1994. [3] It is available as a generic medication. [5] In 2022, it was the 201st most commonly prescribed medication in the United States, with more than 2 million prescriptions. [6] [7]
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Carbonic anhydrase inhibitors: acetazolamide, [17] dorzolamide: Inhibits H + secretion, resultant promotion of Na + and K + excretion 2. proximal tubule: Loop diuretics: bumetanide, [17] ethacrynic acid, [17] furosemide, [17] torsemide: Inhibits the Na-K-2Cl symporter: 3. medullary thick ascending limb: Osmotic diuretics: glucose (especially in ...
Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.Dichlorphenamide as a carbonic anhydrase inhibitor is used for the treatment of acute angle closure glaucoma.
Dorzolamide is a human carboanhydrase II inhibitor. [11] Inhibition of carboanhydrase in the ciliary processes of the eye decreases aqueous humor secretion supposedly by decreasing the formation rate of bicarbonate ions. [12] This results in reduction in both sodium and fluid transport. Timolol is a non-selective beta-adrenergic antagonist. [13]
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