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In immunology, clonal selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response .
He made significant contributions to the clonal selection theory. [2] ... "David W. Talmage and the advent of the cell selection theory of antibody synthesis" (PDF).
Clonal Selection Pseudo code on AISWeb; CLONALG in Matlab developed by Leandro de Castro and Fernando Von Zuben; Optimization Algorithm Toolkit in Java developed by Jason Brownlee which includes the following clonal selection algorithms: Adaptive Clonal Selection (ACS), Optimization Immune Algorithm (opt-IMMALG), Optimization Immune Algorithm (opt-IA), Clonal Selection Algorithm (CLONALG ...
The theory is now sometimes known as Burnet's clonal selection theory, [113] which overlooks the contributions of Ehrlich, Jerne, Talmage, and the contributions of Lederberg, who conceptualised the genetics of clonal selection. [114] Burnet's work on graft-versus-host was in collaboration with Lone Simonsen between 1960 and 1962.
Myriad receptors are produced through a process known as clonal selection. [ 2 ] [ 3 ] According to the clonal selection theory, at birth, an animal randomly generates a vast diversity of lymphocytes (each bearing a unique antigen receptor) from information encoded in a small family of genes.
In the late 1950s however, the works of three scientists—Jerne, Talmage and Burnet (who largely modified the theory)—gave rise to the clonal selection theory, which proved all the elements of Ehrlich's hypothesis except that the specific receptors that could neutralize the agent were soluble and not membrane-bound. [17] [30]
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Clonal Selection Theory and the Rise of Molecular Immunology, Cambridge: Harvard University Press. The Immune Self: Theory or Metaphor? New York and Cambridge: Cambridge University Press, 1994 (Paperback 1996). Italian translation, L'immunologia Dell'io, Milano: McGraw Hill Libri Italia, 1999.